Membranous glomerulonephritis: Difference between revisions
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{{Infobox medical condition | |||
| name = Membranous glomerulonephritis | |||
| image = [[File:Membranous_nephropathy_-_mpas_-_very_high_mag.jpg|250px]] | |||
| caption = Micrograph of membranous glomerulonephritis, showing thickened [[glomerular basement membrane]] and subepithelial deposits. | |||
| field = [[Nephrology]] | |||
| synonyms = Membranous nephropathy | |||
| symptoms = [[Proteinuria]], [[edema]], [[hypertension]], [[hyperlipidemia]] | |||
| complications = [[Chronic kidney disease]], [[thromboembolism]], [[infection]] | |||
| onset = Typically in adults, but can occur at any age | |||
| duration = Chronic | |||
| causes = [[Autoimmune disease]], [[infections]], [[medications]], [[cancer]] | |||
| risks = [[Hepatitis B]], [[Hepatitis C]], [[systemic lupus erythematosus]], [[nonsteroidal anti-inflammatory drugs]] | |||
| diagnosis = [[Urinalysis]], [[blood test]], [[kidney biopsy]] | |||
| differential = [[Focal segmental glomerulosclerosis]], [[minimal change disease]], [[diabetic nephropathy]] | |||
| treatment = [[Immunosuppressive therapy]], [[ACE inhibitors]], [[angiotensin II receptor blockers]], [[statins]] | |||
| prognosis = Variable; some cases resolve spontaneously, others progress to [[end-stage renal disease]] | |||
| frequency = 1 in 100,000 people per year | |||
}} | |||
[[File:Membranous Nephropathy Pathology Diagram.svg|Membranous nephropathy pathology diagram|thumb|left]] | |||
'''Membranous glomerulonephritis''' is a [[kidney disease]] that affects the [[glomeruli]] (the small blood vessels in the kidneys that filter waste from the blood). It is characterized by thickening of the glomerular basement membrane, which leads to the accumulation of immune complexes and the development of proteinuria (excessive protein in the urine). | '''Membranous glomerulonephritis''' is a [[kidney disease]] that affects the [[glomeruli]] (the small blood vessels in the kidneys that filter waste from the blood). It is characterized by thickening of the glomerular basement membrane, which leads to the accumulation of immune complexes and the development of proteinuria (excessive protein in the urine). | ||
== Causes == | == Causes == | ||
The exact cause of membranous glomerulonephritis is unknown, but it is often associated with other medical conditions such as [[lupus]], [[hepatitis B]], [[hepatitis C]], and [[malaria]]. It can also occur as a secondary condition to [[cancer]], [[thyroid disease]], and exposure to certain drugs or toxins. | The exact cause of membranous glomerulonephritis is unknown, but it is often associated with other medical conditions such as [[lupus]], [[hepatitis B]], [[hepatitis C]], and [[malaria]]. It can also occur as a secondary condition to [[cancer]], [[thyroid disease]], and exposure to certain drugs or toxins. | ||
== Symptoms == | == Symptoms == | ||
Symptoms of membranous glomerulonephritis can vary greatly from person to person. Some people may have no symptoms at all, while others may experience [[edema]] (swelling), [[proteinuria]] (excessive protein in the urine), [[hematuria]] (blood in the urine), and [[hypertension]] (high blood pressure). | Symptoms of membranous glomerulonephritis can vary greatly from person to person. Some people may have no symptoms at all, while others may experience [[edema]] (swelling), [[proteinuria]] (excessive protein in the urine), [[hematuria]] (blood in the urine), and [[hypertension]] (high blood pressure). | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of membranous glomerulonephritis is typically made through a combination of [[urine test]], [[blood test]], and [[kidney biopsy]]. The biopsy can confirm the presence of the characteristic thickening of the glomerular basement membrane. | Diagnosis of membranous glomerulonephritis is typically made through a combination of [[urine test]], [[blood test]], and [[kidney biopsy]]. The biopsy can confirm the presence of the characteristic thickening of the glomerular basement membrane. | ||
== Treatment == | == Treatment == | ||
Treatment for membranous glomerulonephritis is aimed at reducing symptoms and slowing the progression of the disease. This may include medications to control blood pressure and reduce proteinuria, as well as dietary changes to limit protein and salt intake. In severe cases, [[dialysis]] or a [[kidney transplant]] may be necessary. | Treatment for membranous glomerulonephritis is aimed at reducing symptoms and slowing the progression of the disease. This may include medications to control blood pressure and reduce proteinuria, as well as dietary changes to limit protein and salt intake. In severe cases, [[dialysis]] or a [[kidney transplant]] may be necessary. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for membranous glomerulonephritis can vary greatly depending on the severity of the disease and the individual's overall health. Some people may experience a complete recovery, while others may develop chronic kidney disease or end-stage renal disease. | The prognosis for membranous glomerulonephritis can vary greatly depending on the severity of the disease and the individual's overall health. Some people may experience a complete recovery, while others may develop chronic kidney disease or end-stage renal disease. | ||
[[Category:Kidney diseases]] | [[Category:Kidney diseases]] | ||
[[Category:Glomerular diseases]] | [[Category:Glomerular diseases]] | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 21:16, 9 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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| Membranous glomerulonephritis | |
|---|---|
| |
| Synonyms | Membranous nephropathy |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Proteinuria, edema, hypertension, hyperlipidemia |
| Complications | Chronic kidney disease, thromboembolism, infection |
| Onset | Typically in adults, but can occur at any age |
| Duration | Chronic |
| Types | N/A |
| Causes | Autoimmune disease, infections, medications, cancer |
| Risks | Hepatitis B, Hepatitis C, systemic lupus erythematosus, nonsteroidal anti-inflammatory drugs |
| Diagnosis | Urinalysis, blood test, kidney biopsy |
| Differential diagnosis | Focal segmental glomerulosclerosis, minimal change disease, diabetic nephropathy |
| Prevention | N/A |
| Treatment | Immunosuppressive therapy, ACE inhibitors, angiotensin II receptor blockers, statins |
| Medication | N/A |
| Prognosis | Variable; some cases resolve spontaneously, others progress to end-stage renal disease |
| Frequency | 1 in 100,000 people per year |
| Deaths | N/A |
Membranous glomerulonephritis is a kidney disease that affects the glomeruli (the small blood vessels in the kidneys that filter waste from the blood). It is characterized by thickening of the glomerular basement membrane, which leads to the accumulation of immune complexes and the development of proteinuria (excessive protein in the urine).
Causes[edit]
The exact cause of membranous glomerulonephritis is unknown, but it is often associated with other medical conditions such as lupus, hepatitis B, hepatitis C, and malaria. It can also occur as a secondary condition to cancer, thyroid disease, and exposure to certain drugs or toxins.
Symptoms[edit]
Symptoms of membranous glomerulonephritis can vary greatly from person to person. Some people may have no symptoms at all, while others may experience edema (swelling), proteinuria (excessive protein in the urine), hematuria (blood in the urine), and hypertension (high blood pressure).
Diagnosis[edit]
Diagnosis of membranous glomerulonephritis is typically made through a combination of urine test, blood test, and kidney biopsy. The biopsy can confirm the presence of the characteristic thickening of the glomerular basement membrane.
Treatment[edit]
Treatment for membranous glomerulonephritis is aimed at reducing symptoms and slowing the progression of the disease. This may include medications to control blood pressure and reduce proteinuria, as well as dietary changes to limit protein and salt intake. In severe cases, dialysis or a kidney transplant may be necessary.
Prognosis[edit]
The prognosis for membranous glomerulonephritis can vary greatly depending on the severity of the disease and the individual's overall health. Some people may experience a complete recovery, while others may develop chronic kidney disease or end-stage renal disease.
