Ilaprazole

Overview of the proton pump inhibitor Ilaprazole

Ilaprazole
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Ilaprazole is a proton pump inhibitor (PPI) used in the treatment of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid production. It is known for its long-lasting effect and is used in various countries for managing acid-related disorders.

Mechanism of Action

Ilaprazole works by inhibiting the H+/K+ ATPase enzyme system, also known as the proton pump, in the parietal cells of the stomach lining. This inhibition prevents the final step of acid production, thereby reducing gastric acidity.

Pharmacokinetics

Ilaprazole is absorbed in the small intestine and undergoes hepatic metabolism primarily via the cytochrome P450 enzyme system. It has a longer half-life compared to other PPIs, which contributes to its prolonged action.

Clinical Uses

Ilaprazole is primarily used for:

• Gastroesophageal reflux disease (GERD)
• Peptic ulcer disease
• Zollinger-Ellison syndrome

Side Effects

Common side effects of Ilaprazole include:

• Headache
• Nausea
• Diarrhea
• Abdominal pain

Comparison with Other PPIs

Ilaprazole is often compared with other PPIs such as omeprazole, lansoprazole, and pantoprazole. It is noted for its longer duration of action and potentially fewer drug interactions.

Related pages

• Proton pump inhibitor
• Gastroesophageal reflux disease
• Peptic ulcer disease

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  Ilaprazole chemical structure