Trestolone enanthate: Difference between revisions

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'''Trestolone enanthate''' is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of [[nandrolone]] which was never marketed. It is an androgen ester – specifically, the C17β enanthate ester of [[trestolone]] (7α-methyl-19-nortestosterone; MENT).
{{DISPLAYTITLE:Trestolone Enanthate}}


==Pharmacology==
== Overview ==
As an [[AAS]], trestolone enanthate is an [[agonist]] of the [[androgen receptor]] (AR), the biological target of androgens like [[testosterone]] and [[dihydrotestosterone]] (DHT). It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women. The drug has no estrogenic effects but can have progestogenic effects, which can mimic estrogenic side effects.
[[File:Trestolone_enanthate.svg|thumb|right|Chemical structure of Trestolone Enanthate]]
'''Trestolone Enanthate''' is a synthetic [[androgen]] and [[anabolic steroid]] (AAS) that is used in [[medical research]] and has potential applications in [[hormone replacement therapy]] and [[contraception]]. It is an esterified form of [[trestolone]], also known as 7_-methyl-19-nortestosterone (MENT), which is a potent [[androgen receptor]] agonist.


==Chemistry==
== Chemical Properties ==
Trestolone enanthate, also known as 7α-methyl-19-nortestosterone 17β-enanthate, is a synthetic [[estrane]] steroid and a derivative of [[nandrolone]]. It is more specifically a derivative of [[19-nortestosterone]] and is a member of the estrane group, while a derivative of [[17β-hydroxyestra-4,9,11-trien-3-one]] (trenbolone), a derivative of [[progesterone]], is a member of the [[estratetraene]] group.
Trestolone Enanthate is characterized by the addition of an enanthate ester to the 17_-hydroxyl group of trestolone. This modification increases the [[lipophilicity]] of the compound, allowing for a prolonged release and action when administered via [[intramuscular injection]]. The chemical structure of Trestolone Enanthate is depicted in the adjacent image.


==History==
== Mechanism of Action ==
Trestolone enanthate was first described in the literature in 1963. It was studied for use in male hormonal contraception and treatment of male hypogonadism but was never marketed.
Trestolone Enanthate acts by binding to the androgen receptor, mimicking the effects of natural [[testosterone]]. It promotes the development and maintenance of male secondary sexual characteristics and has significant [[anabolic]] effects, which include the stimulation of [[muscle]] growth and [[bone]] density.


==Society and culture==
== Clinical Applications ==
Trestolone enanthate is not currently approved for medical use and it is not available as a prescription medication. However, it has been sold on the internet as a designer steroid for bodybuilders and other athletes.
Trestolone Enanthate is primarily investigated for its potential use in [[male contraception]]. It suppresses [[spermatogenesis]] by inhibiting the secretion of [[gonadotropins]] from the [[pituitary gland]], thereby reducing [[testosterone]] production in the [[testes]]. Additionally, it is being studied for its use in [[hormone replacement therapy]] for men with [[hypogonadism]].


==See also==
== Side Effects ==
* [[List of androgen esters]]
As with other anabolic steroids, the use of Trestolone Enanthate can lead to side effects such as [[acne]], [[gynecomastia]], [[hypertension]], and alterations in [[lipid]] profiles. Long-term use may also affect [[liver]] function and increase the risk of [[cardiovascular disease]].
* [[List of androgen esters § Trestolone esters]]
 
== Administration ==
Trestolone Enanthate is typically administered via intramuscular injection. The dosing regimen depends on the specific clinical application and the individual patient's response to therapy.
 
== Related Pages ==
* [[Androgen]]
* [[Anabolic steroid]]
* [[Hormone replacement therapy]]
* [[Male contraception]]
* [[Hypogonadism]]


[[Category:Androgens and anabolic steroids]]
[[Category:Androgens and anabolic steroids]]
[[Category:Androgen esters]]
[[Category:Hormonal contraception]]
[[Category:Estranes]]
[[Category:Progestogen esters]]
{{Anabolic-androgenic steroids}}
{{Androgen ester stub}}

Latest revision as of 05:27, 16 February 2025


Overview[edit]

Chemical structure of Trestolone Enanthate

Trestolone Enanthate is a synthetic androgen and anabolic steroid (AAS) that is used in medical research and has potential applications in hormone replacement therapy and contraception. It is an esterified form of trestolone, also known as 7_-methyl-19-nortestosterone (MENT), which is a potent androgen receptor agonist.

Chemical Properties[edit]

Trestolone Enanthate is characterized by the addition of an enanthate ester to the 17_-hydroxyl group of trestolone. This modification increases the lipophilicity of the compound, allowing for a prolonged release and action when administered via intramuscular injection. The chemical structure of Trestolone Enanthate is depicted in the adjacent image.

Mechanism of Action[edit]

Trestolone Enanthate acts by binding to the androgen receptor, mimicking the effects of natural testosterone. It promotes the development and maintenance of male secondary sexual characteristics and has significant anabolic effects, which include the stimulation of muscle growth and bone density.

Clinical Applications[edit]

Trestolone Enanthate is primarily investigated for its potential use in male contraception. It suppresses spermatogenesis by inhibiting the secretion of gonadotropins from the pituitary gland, thereby reducing testosterone production in the testes. Additionally, it is being studied for its use in hormone replacement therapy for men with hypogonadism.

Side Effects[edit]

As with other anabolic steroids, the use of Trestolone Enanthate can lead to side effects such as acne, gynecomastia, hypertension, and alterations in lipid profiles. Long-term use may also affect liver function and increase the risk of cardiovascular disease.

Administration[edit]

Trestolone Enanthate is typically administered via intramuscular injection. The dosing regimen depends on the specific clinical application and the individual patient's response to therapy.

Related Pages[edit]