Spiperone: Difference between revisions

Latest revision as of 04:03, 13 February 2025

Spiperone[edit]

Spiperone is a butyrophenone antipsychotic drug primarily used in research settings. It is known for its high affinity for dopamine D2 receptors and serotonin 5-HT2A receptors, making it a valuable tool in the study of these neurotransmitter systems.

Pharmacology[edit]

Spiperone acts as a potent antagonist at the dopamine D2 receptors and serotonin 5-HT2A receptors. This dual action is significant in understanding the mechanisms of antipsychotic drugs and their effects on the central nervous system.

Mechanism of Action[edit]

Spiperone binds to the dopamine D2 receptors, inhibiting the action of dopamine, a neurotransmitter involved in mood, reward, and motor control. By blocking these receptors, spiperone can modulate the effects of dopamine, which is crucial in the treatment of schizophrenia and other psychotic disorders.

Additionally, spiperone's action on serotonin 5-HT2A receptors contributes to its effects on mood and perception, providing insights into the treatment of depression and anxiety disorders.

Uses in Research[edit]

Spiperone is extensively used in neuroscience research to study the role of dopamine and serotonin in the brain. Its ability to selectively block specific receptors makes it a valuable tool in pharmacological studies and brain imaging techniques such as positron emission tomography (PET).

Side Effects[edit]

While spiperone is not commonly used in clinical practice, its side effects are similar to those of other butyrophenone antipsychotics. These may include extrapyramidal symptoms, such as tremors, rigidity, and bradykinesia, as well as sedation and hypotension.

Related Pages[edit]

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-'''Spiperone''' is a [[butyrophenone]] based [[antipsychotic]] and [[research chemical]] that was first introduced by [[Janssen Pharmaceutica]] in 1978. It is most commonly used in scientific research and has been shown to be particularly useful in the study of [[dopamine]] and [[serotonin]] receptors in the brain.
+== Spiperone ==
-==Chemical Structure and Properties==
+[[File:Spiperone.svg|thumb|right|Chemical structure of Spiperone]]
-Spiperone is a synthetic compound of the butyrophenone class. It is structurally related to other butyrophenone antipsychotics such as [[haloperidol]] and [[droperidol]]. The chemical formula of spiperone is C23H26FN3O2 and its molecular weight is 395.47 g/mol.
-==Pharmacology==
+'''Spiperone''' is a [[butyrophenone]] [[antipsychotic]] drug primarily used in [[research]] settings. It is known for its high affinity for [[dopamine]] D2 receptors and [[serotonin]] 5-HT2A receptors, making it a valuable tool in the study of these neurotransmitter systems.
-Spiperone acts as an antagonist at both dopamine D2 and D3 receptors, and serotonin 5-HT2A and 5-HT1A receptors. It has high affinity for these receptors and is often used in research to label and study them. Spiperone has been used in the development of radioligands for the study of dopamine and serotonin receptors in the brain.
-==Clinical Use==
+== Pharmacology ==
-While spiperone is not typically used in clinical practice due to its side effects, it has been used in research settings to study various neurological and psychiatric disorders. These include [[schizophrenia]], [[Parkinson's disease]], and [[depression]].
-==Side Effects==
+Spiperone acts as a potent [[antagonist]] at the [[dopamine receptor|dopamine D2 receptors]] and [[serotonin receptor|serotonin 5-HT2A receptors]]. This dual action is significant in understanding the mechanisms of [[antipsychotic drugs]] and their effects on the [[central nervous system]].
-Like other butyrophenone antipsychotics, spiperone can cause a range of side effects. These can include [[extrapyramidal symptoms]], [[tardive dyskinesia]], and [[neuroleptic malignant syndrome]]. Due to these potential side effects, spiperone is not commonly used in clinical practice.
-==See Also==
+=== Mechanism of Action ===
+Spiperone binds to the dopamine D2 receptors, inhibiting the action of dopamine, a neurotransmitter involved in mood, reward, and motor control. By blocking these receptors, spiperone can modulate the effects of dopamine, which is crucial in the treatment of [[schizophrenia]] and other [[psychotic disorders]].
+Additionally, spiperone's action on serotonin 5-HT2A receptors contributes to its effects on mood and perception, providing insights into the treatment of [[depression]] and [[anxiety disorders]].
+== Uses in Research ==
+Spiperone is extensively used in [[neuroscience]] research to study the role of dopamine and serotonin in the brain. Its ability to selectively block specific receptors makes it a valuable tool in [[pharmacological]] studies and [[brain imaging]] techniques such as [[positron emission tomography]] (PET).
+== Side Effects ==
+While spiperone is not commonly used in clinical practice, its side effects are similar to those of other butyrophenone antipsychotics. These may include [[extrapyramidal symptoms]], such as [[tremors]], [[rigidity]], and [[bradykinesia]], as well as [[sedation]] and [[hypotension]].
+== Related Pages ==
+* [[Antipsychotic]]
+* [[Dopamine receptor]]
+* [[Serotonin receptor]]
 * [[Butyrophenone]]
-* [[Antipsychotic]]
+* [[Schizophrenia]]
-* [[Dopamine]]
-* [[Serotonin]]
-* [[Haloperidol]]
-* [[Droperidol]]
 [[Category:Antipsychotics]]
 [[Category:Butyrophenones]]
 [[Category:Research chemicals]]
-[[Category:Janssen Pharmaceutica]]
-{{stub}}