Zollinger–Ellison syndrome

Zollinger–Ellison syndrome (pronunciation: Zol-ing-er El-li-son sin-drome) is a complex medical condition that is characterized by the development of gastrinoma, a type of neuroendocrine tumor that secretes excessive amounts of the hormone gastrin. This overproduction of gastrin leads to the excessive secretion of gastric acid, which can result in severe ulcers in the stomach and duodenum, and can also cause diarrhea and gastroesophageal reflux disease (GERD).

Etymology

The syndrome is named after the American surgeons Robert Zollinger and Edwin Ellison, who first described the condition in 1955.

Symptoms

The most common symptoms of Zollinger–Ellison syndrome include abdominal pain, diarrhea, and heartburn. These symptoms are caused by the excessive production of gastric acid, which can damage the lining of the stomach and duodenum.

Diagnosis

The diagnosis of Zollinger–Ellison syndrome is typically confirmed through a series of tests, including blood tests to measure levels of gastrin, and imaging tests such as computed tomography (CT) scans or magnetic resonance imaging (MRI) to identify the presence of tumors.

Treatment

The treatment for Zollinger–Ellison syndrome typically involves medications to reduce the production of gastric acid, and in some cases, surgery to remove the tumors. In cases where the tumors have spread to other parts of the body, chemotherapy may be used.

Related Terms

External links

Medical encyclopedia article on Zollinger–Ellison syndrome
Wikipedia's article - Zollinger–Ellison syndrome

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