Vascular-targeting agent
A vascular-targeting agent (VTA) or vascular disrupting agent (VDA) is a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.[1]
VTAs can be small-molecule or ligand-based.
Small-molecule VTAs include:
- microtubule destabilizing drugs such as combretastatin A-4 disodium phosphate (CA4P), ZD6126, AVE8062, Oxi 4503
- vadimezan (ASA404)
Clinical trials[edit]
Phase II : ZD6126, CA4P, plinabulin (NPI-2358)[2][3][4]
Phase III : DMXAA (ASA404).
References[edit]
- ↑ "Vascular Targeting Agents as Cancer Therapeutics".2004;Full text.
- ↑ NPI-2358(link). clinicaltrials.gov.
- ↑ Monica M. Mita."Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin (NPI-2358) in Patients with Solid Tumors or Lymphomas".Clin Cancer Res.2010;16(23)
- 5892–5899.doi:10.1158/1078-0432.CCR-10-1096.PMID:21138873.
- ↑ Staff."Clinical Trials Update".Genetic Engineering & Biotechnology News.2009;29(8)
- 58.
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