Triparanol
Triparanol (pronounced: tri-par-a-nol) is a cholesterol lowering drug that was first introduced in the 1960s. It is also known by its trade name, Mer/29.
Etymology
The term "Triparanol" is derived from its chemical structure, which consists of three para positions on the benzene ring.
Pharmacology
Triparanol works by inhibiting the enzyme desmosterol reductase, which is involved in the final step of cholesterol synthesis. This results in a decrease in the levels of cholesterol in the body.
History
Triparanol was first introduced in the 1960s by the pharmaceutical company Merck & Co. However, it was withdrawn from the market in 1962 due to severe side effects, including cataracts, hair loss, and skin abnormalities.
Side Effects
The side effects of Triparanol include cataracts, hair loss, and skin abnormalities. These side effects were severe enough to lead to the withdrawal of the drug from the market.
Related Terms
External links
- Medical encyclopedia article on Triparanol
- Wikipedia's article - Triparanol
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