Tolebrutinib
A medication under investigation for multiple sclerosis and other autoimmune diseases
| Tolebrutinib | |
|---|---|
| [[File:|frameless|220px|alt=|]] | |
| INN | |
| Drug class | |
| Routes of administration | Oral |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | Investigational |
| CAS Number | 1971929-97-7 |
| PubChem | 129073382 |
| DrugBank | |
| ChemSpider | 68012192 |
| KEGG | D11792 |
Overview
Tolebrutinib is an investigational Bruton tyrosine kinase (BTK) inhibitor being developed for the treatment of multiple sclerosis (MS) and other autoimmune diseases. It is designed to modulate the immune system by inhibiting the activity of BTK, a key enzyme involved in the signaling pathways of B cells and myeloid cells.
Mechanism of Action
Tolebrutinib works by selectively inhibiting BTK, which plays a crucial role in the activation and function of B cells and other immune cells. By blocking BTK, tolebrutinib aims to reduce the abnormal immune response that characterizes autoimmune diseases such as multiple sclerosis. This inhibition can potentially decrease the inflammation and damage to the nervous system seen in MS.
Clinical Development
Tolebrutinib is currently undergoing clinical trials to evaluate its safety and efficacy in patients with multiple sclerosis. These trials are designed to assess the drug's ability to reduce the frequency of relapses and slow the progression of disability in MS patients. The drug is administered orally, which may offer a convenient alternative to injectable therapies currently available for MS.
Potential Indications
While the primary focus of tolebrutinib's development is for the treatment of multiple sclerosis, its mechanism of action suggests potential applications in other autoimmune diseases. The inhibition of BTK could be beneficial in conditions where B cells and myeloid cells play a significant role in disease pathology.
Safety and Tolerability
The safety profile of tolebrutinib is being closely monitored in clinical trials. As with any investigational drug, potential side effects and adverse reactions are being evaluated to ensure the drug's safety for future use in patients.
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Contributors: Prab R. Tumpati, MD
