Tiazesim

Tiazesim', known by its International Nonproprietary Name (INN) as Tiazesim, and by its British Approved Name (BAN) and United States Adopted Name (USAN) as Thiazesim, is a heterocyclic antidepressant that bears a structural and pharmacological relationship to the tricyclic antidepressants (TCAs). First introduced to the market in 1966 by Squibb Corporation, which has since become part of Bristol-Myers Squibb, Tiazesim was previously sold under the brand name Altinil. However, it has been discontinued and is no longer available on the market.

Pronunciation

Tie-ah-zee-sim

Etymology

The name "Tiazesim" likely derives from the chemical structure of the compound, which contains a thiazine ring – a heterocyclic compound containing both sulfur and nitrogen. The suffix "-sim" is common among pharmaceuticals but does not have a specific meaning.

Pharmacology

As a member of the heterocyclic antidepressant class, Tiazesim shares many of the pharmacological properties of tricyclic antidepressants. These compounds typically exert their effects by inhibiting the reuptake of neurotransmitters such as serotonin and norepinephrine, thereby increasing their concentration in the synaptic cleft and enhancing neurotransmission. The exact mechanism of action of Tiazesim, like many TCAs, involves multiple targets and is not fully understood.

Clinical Use and Discontinuation

Upon its introduction, Tiazesim was intended for the treatment of depression, offering an alternative to other antidepressants available at the time. Despite its initial promise, the use of Tiazesim has been discontinued, and it is no longer marketed. The reasons for discontinuation can vary, including but not limited to, the development of more effective or safer alternatives, commercial decisions, or concerns related to efficacy or safety.

Related Terms

• Antidepressant
• Tricyclic Antidepressant
• Depression
• Pharmacology

See Also

• History of Antidepressants
• Pharmacological Treatment of Depression
• Discontinued Drugs

External links

• Medical encyclopedia article on Tiazesim
• Wikipedia's article - Tiazesim

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