Thioxanthenes

Thioxanthenes

Thioxanthenes (pronounced: thy-ox-an-thens) are a class of Antipsychotic drugs used primarily in the treatment of Schizophrenia and other Psychotic disorders. The term "thioxanthenes" is derived from the chemical structure of these drugs, which includes a thioxanthene nucleus.

History

The development of thioxanthenes began in the mid-20th century as part of the search for more effective treatments for schizophrenia and other psychotic disorders. The first thioxanthene antipsychotic, Chlorprothixene, was introduced in the 1950s.

Pharmacology

Thioxanthenes work by blocking Dopamine receptors in the brain, particularly the D2 receptor. This reduces the overactivity of dopamine, which is thought to be a factor in the development of psychotic symptoms. Some thioxanthenes also have Anticholinergic effects, which can help to reduce the side effects of other antipsychotic drugs.

Types of Thioxanthenes

There are several different types of thioxanthenes, including:

• Chlorprothixene
• Thiothixene
• Flupenthixol

Each of these drugs has slightly different properties, but all are used to treat psychotic disorders.

Side Effects

Like all antipsychotic drugs, thioxanthenes can have side effects. These can include Drowsiness, Dry mouth, Blurred vision, and Constipation. In rare cases, they can also cause more serious side effects such as Tardive dyskinesia, a movement disorder.

Related Terms

• Antipsychotic drugs
• Dopamine receptors
• Schizophrenia
• Psychotic disorders
• Anticholinergic
• Tardive dyskinesia

This WikiMD.org article is a stub. You can help make it a full article.