TRPV3-74a

TRPV3

Structure of TRPV3-74a

TRPV3 is a member of the transient receptor potential channel family, specifically the TRPV subfamily, which is involved in various physiological processes. TRPV3 is a cation channel that is activated by warm temperatures and certain chemical compounds. It plays a significant role in thermosensation, skin physiology, and pain perception.

Structure

TRPV3 is a transmembrane protein that forms a tetrameric channel. Each subunit of TRPV3 consists of six transmembrane domains with a pore region between the fifth and sixth domains. The channel is permeable to calcium ions and other cations. The structure of TRPV3-74a, a specific form of TRPV3, has been elucidated using cryo-electron microscopy, revealing details about its gating mechanism and ion selectivity.

Function

TRPV3 is primarily expressed in the skin, keratinocytes, and hair follicles. It is activated by warm temperatures in the range of 31-39°C and by various chemical agonists such as camphor and eugenol. Upon activation, TRPV3 allows the influx of calcium ions, which can trigger various downstream signaling pathways.

Role in Skin Physiology

In the skin, TRPV3 is involved in the regulation of keratinocyte proliferation and differentiation. It contributes to the maintenance of the skin barrier and is implicated in the sensation of warmth. Abnormal TRPV3 function has been associated with skin disorders such as atopic dermatitis and itching.

Role in Pain Perception

TRPV3 is also expressed in sensory neurons and contributes to the perception of pain. It is involved in the detection of noxious heat and chemical stimuli. Modulation of TRPV3 activity has been explored as a potential therapeutic target for pain management.

Pharmacology

TRPV3 can be modulated by various pharmacological agents. Agonists such as camphor and eugenol activate the channel, while antagonists can inhibit its activity. Understanding the pharmacology of TRPV3 is important for developing treatments for conditions associated with its dysfunction.

Related pages

• TRPV1
• TRPV2
• TRPV4
• Thermoreception
• Ion channel