Solute carrier organic anion transporter family member 1B1

Solute carrier organic anion transporter family member 1B1 (SLCO1B1) is a protein that in humans is encoded by the SLCO1B1 gene. This protein is a member of the organic anion transporter (OATP) family, which is responsible for the uptake and transport of various endogenous substances and xenobiotics in the body.

Function

The SLCO1B1 gene encodes a protein that is involved in the transport of bilirubin, thyroid hormones, and various drugs across the hepatocyte membrane. This protein is primarily expressed in the liver, where it plays a crucial role in the detoxification process.

Clinical significance

Mutations in the SLCO1B1 gene have been associated with various medical conditions. For instance, certain variants of this gene have been linked to an increased risk of statin-induced myopathy, a condition characterized by muscle weakness and pain. Furthermore, alterations in the function of the SLCO1B1 protein can affect the body's response to certain medications, potentially leading to drug toxicity or reduced therapeutic efficacy.

See also

• Organic anion-transporting polypeptide
• Solute carrier family

External links

• GeneReviews/NCBI/NIH/UW entry on SLCO1B1