Sodoku
| Sodoku | |
|---|---|
| Synonyms | Rat-bite fever | 
| Pronounce | N/A | 
| Specialty | N/A | 
| Symptoms | Fever, rash, arthritis | 
| Complications | Endocarditis, meningitis | 
| Onset | 3–10 days after exposure | 
| Duration | Variable | 
| Types | N/A | 
| Causes | Streptobacillus moniliformis or Spirillum minus | 
| Risks | Rat bites or exposure to rodents | 
| Diagnosis | Blood culture, serology | 
| Differential diagnosis | Leptospirosis, syphilis, Lyme disease | 
| Prevention | Avoiding contact with rodents | 
| Treatment | Antibiotics such as penicillin or doxycycline | 
| Medication | N/A | 
| Prognosis | Good with treatment | 
| Frequency | Rare | 
| Deaths | N/A | 
Sodoku is a bacterial zoonotic disease caused by the bacterium Spirillum minus or Streptobacillus moniliformis. It is primarily transmitted through the bite of an infected rat, although other rodents can also be carriers. The disease is also known as rat-bite fever, spirillary rat-bite fever, or Haverhill fever.
Symptoms
The symptoms of Sodoku typically appear within 7 to 21 days after exposure to the bacteria. These symptoms may include:
- Fever
 - Chills
 - Headache
 - Muscle and joint pain
 - Rash
 - Swelling at the site of the bite
 
In severe cases, complications such as endocarditis, meningitis, and pneumonia can occur.
Diagnosis
Diagnosis of Sodoku is typically made based on the patient's symptoms and history of exposure to rats or other rodents. Laboratory tests can also be used to confirm the diagnosis, including blood cultures and serologic tests.
Treatment
Treatment for Sodoku typically involves antibiotics to kill the bacteria. Penicillin is the most commonly used antibiotic, although other antibiotics may be used in patients who are allergic to penicillin. In severe cases, hospitalization may be required.
Prevention
Prevention of Sodoku primarily involves avoiding contact with rats and other rodents, particularly in areas where the disease is known to occur. This can include using rodent-proof containers for food and garbage, sealing holes and gaps in homes and buildings, and using traps or poisons to control rodent populations.
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Contributors: Prab R. Tumpati, MD