Signet ring cell

Signet Ring Cell

Signet ring cell carcinoma - very high mag

A Signet Ring Cell is a type of cell that can be seen in certain types of cancer, most notably gastric (stomach) cancer and colorectal cancer. These cells are characterized by a large vacuole that pushes the nucleus to the periphery, giving the cell an appearance similar to a signet ring.

Characteristics

Signet ring cells are characterized by their unique appearance, which is caused by the presence of a large vacuole of mucin that pushes the cell's nucleus to one side. This gives the cell an appearance similar to a signet ring, hence the name. The presence of these cells in a tumor is usually indicative of a more aggressive and invasive form of cancer.

Associated Cancers

Signet ring cells are most commonly associated with gastric cancer, but they can also be found in other types of cancer, such as colorectal cancer, breast cancer, bladder cancer, and pancreatic cancer. The presence of signet ring cells in these cancers is usually indicative of a poor prognosis.

Diagnosis

Signet ring cell carcinoma - intermed mag

Diagnosis of signet ring cell carcinoma is typically made through a combination of radiological imaging, biopsy, and histopathological examination. The presence of signet ring cells can be confirmed through microscopic examination of biopsy samples.

Treatment

Treatment for cancers that contain signet ring cells typically involves a combination of surgical resection, chemotherapy, and radiation therapy. The specific treatment plan will depend on the type and stage of the cancer, as well as the patient's overall health.

Prognosis

The prognosis for patients with signet ring cell carcinoma is generally poor, due to the aggressive nature of these cancers. However, early detection and treatment can improve survival rates.

See Also

• Gastric cancer
• Colorectal cancer
• Histopathology