Secondary systemic amyloidosis
Secondary Systemic Amyloidosis
Secondary systemic amyloidosis (pronunciation: /ˌsɛkənˈdɛri sɪˌstɛmɪk ˌæmɪˈlɔɪˈdoʊsɪs/) is a form of amyloidosis that is typically associated with chronic inflammatory conditions.
Etymology
The term "secondary systemic amyloidosis" is derived from the Greek words "amyloid" meaning "starch-like" and "osis" meaning "condition". The prefix "secondary" is used to denote that the condition is a result of another underlying disease or condition.
Definition
Secondary systemic amyloidosis is a disorder characterized by the deposition of insoluble protein aggregates, known as amyloid fibrils, in various organs and tissues of the body. This condition is considered secondary because it often occurs as a complication of another disease that causes prolonged inflammation, such as rheumatoid arthritis, inflammatory bowel disease, or tuberculosis.
Symptoms
The symptoms of secondary systemic amyloidosis can vary widely depending on the organs affected. Common symptoms may include fatigue, weight loss, and swelling in the legs and ankles due to kidney disease. If the heart is affected, symptoms may include shortness of breath, irregular heartbeat, and fluid retention.
Diagnosis
Diagnosis of secondary systemic amyloidosis typically involves a combination of physical examination, medical history, and laboratory tests. A definitive diagnosis is usually made through a biopsy of affected tissue, which is then examined under a microscope for the presence of amyloid deposits.
Treatment
Treatment for secondary systemic amyloidosis primarily focuses on managing the underlying disease causing the inflammation. This may involve the use of anti-inflammatory medications, immune system suppressants, or other treatments specific to the underlying condition. In some cases, chemotherapy or stem cell transplantation may be used to slow the progression of the disease.
Related Terms
- Primary systemic amyloidosis
- Hereditary amyloidosis
- Localized amyloidosis
- Amyloid
- Chronic inflammation
- Protein aggregation
External links
- Medical encyclopedia article on Secondary systemic amyloidosis
- Wikipedia's article - Secondary systemic amyloidosis
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