Sclerosing rhabdomyosarcoma
| Sclerosing rhabdomyosarcoma | |
|---|---|
| Synonyms | |
| Pronounce | N/A |
| Specialty | Oncology, Pathology |
| Symptoms | Swelling, pain, mass |
| Complications | N/A |
| Onset | |
| Duration | |
| Types | |
| Causes | Unknown |
| Risks | |
| Diagnosis | Biopsy, immunohistochemistry |
| Differential diagnosis | Osteosarcoma, chondrosarcoma, fibrosarcoma |
| Prevention | |
| Treatment | Surgery, chemotherapy, radiation therapy |
| Medication | |
| Prognosis | Variable, depends on stage and location |
| Frequency | Rare |
| Deaths | |
Sclerosing rhabdomyosarcoma is a rare subtype of rhabdomyosarcoma, a type of cancer that develops from skeletal muscle cells. It is characterized by its sclerosing or hardening nature, which distinguishes it from other forms of rhabdomyosarcoma.
Overview
Sclerosing rhabdomyosarcoma is a rare and aggressive form of rhabdomyosarcoma. It is characterized by a distinctive pattern of hyalinization and sclerosis, which gives the tumor its name. The tumor cells are typically small, round, and blue, with a high nuclear-to-cytoplasmic ratio. They often form nests or cords, surrounded by a dense, hyalinized, sclerotic stroma.
Diagnosis
The diagnosis of sclerosing rhabdomyosarcoma is based on the histological appearance of the tumor, as well as the results of immunohistochemistry studies. The tumor cells typically express desmin, myogenin, and MyoD1, which are markers of skeletal muscle differentiation.
Treatment
The treatment of sclerosing rhabdomyosarcoma typically involves a combination of surgery, radiation therapy, and chemotherapy. The choice of treatment depends on the size and location of the tumor, as well as the patient's overall health.
Prognosis
The prognosis for patients with sclerosing rhabdomyosarcoma is generally poor, due to the aggressive nature of the disease and the high likelihood of metastasis. However, early detection and aggressive treatment can improve survival rates.
See also
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Contributors: Prab R. Tumpati, MD
