S100A10

S100A10 is a protein that in humans is encoded by the S100A10 gene. It is also known as p11, or annexin II light chain, calpactin I light chain, and is a member of the S100 protein family. This protein is a type of calcium-binding protein and plays a role in various cellular processes.

Function

The S100A10 protein is known to regulate cellular processes such as cell cycle progression and differentiation. It is also involved in the regulation of membrane trafficking and signal transduction, playing a crucial role in cellular communication. The protein is also known to interact with Annexin A2, forming a complex that has been implicated in the regulation of cellular growth and in signal transduction pathways.

Clinical significance

Alterations in the expression of the S100A10 protein have been associated with a variety of diseases, including cancer. Overexpression of S100A10 has been observed in several types of cancer, including breast cancer, colorectal cancer, and lung cancer. This overexpression has been linked to increased cancer cell growth, invasion, and metastasis.

In addition to its role in cancer, S100A10 has also been implicated in other diseases. For example, alterations in the expression of S100A10 have been associated with neurological disorders, including depression and schizophrenia.

See also

• S100 proteins
• Annexin A2
• Calcium-binding proteins

References

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External links

• NCBI Gene
• UniProt

• S100A10
  S100A10