RpoN

RpoN (also known as Sigma-54) is a sigma factor used in bacterial transcription. It is a part of the RNA polymerase complex and is responsible for the initiation of transcription in bacteria. RpoN is unique among sigma factors due to its requirement for activator proteins to initiate transcription.

Function

RpoN is involved in the transcription of genes related to nitrogen metabolism, flagellar biosynthesis, and virulence factors in pathogenic bacteria. It recognizes and binds to the -24/-12 promoter sequence, which is different from the -35/-10 promoter sequence recognized by the primary sigma factor, Sigma 70.

Structure

RpoN has a unique structure compared to other sigma factors. It consists of four domains, with the fourth domain (Region IV) being responsible for recognizing and binding to the -24/-12 promoter sequence. This domain is also involved in the interaction with the activator proteins.

Role in Disease

RpoN has been implicated in the virulence of several pathogenic bacteria, including Pseudomonas aeruginosa, Salmonella spp., and Escherichia coli. In these bacteria, RpoN controls the expression of genes involved in the production of virulence factors, making it a potential target for the development of new antibacterial drugs.

See Also

• Sigma factor
• Transcription (biology)
• RNA polymerase
• Pseudomonas aeruginosa
• Salmonella
• Escherichia coli

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References

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External Links

• UniProt: RpoN
• NCBI Gene: rpoN