Rosenthal fiber
Rosenthal fiber
Rosenthal fiber (/roʊˈzɛnθɑːl ˈfaɪbər/) is a type of eosinophilic deposit found in the brain. These fibers are named after the German pathologist Karl Rosenthal, who first described them in 1898.
Etymology
The term "Rosenthal fiber" is derived from the name of the German pathologist Karl Rosenthal, who first identified these fibers. The word "fiber" comes from the Latin "fibra", meaning "a thread or filament".
Description
Rosenthal fibers are elongated, eosinophilic (acidophilic), rod-shaped structures found in the astrocytes of the brain. They are composed of glial fibrillary acidic protein (GFAP) and small heat shock proteins, including alphaB-crystallin and HSP27. These fibers are typically found in various neurological disorders, including Alexander disease, pilocytic astrocytoma, and progressive multifocal leukoencephalopathy.
Related Terms
- Eosinophilic: A term used to describe cells or material that stains readily with eosin, a red acidic dye.
- Astrocytes: Star-shaped glial cells in the brain and spinal cord.
- Glial fibrillary acidic protein (GFAP): A protein that is encoded by the GFAP gene in humans.
- AlphaB-crystallin: A small heat shock protein that in humans is encoded by the CRYAB gene.
- HSP27: A small heat shock protein that in humans is encoded by the HSPB1 gene.
- Alexander disease: A rare and often fatal neurodegenerative disease.
- Pilocytic astrocytoma: A brain tumor that occurs more often in children and young adults.
- Progressive multifocal leukoencephalopathy (PML): A rare and often fatal viral disease characterized by progressive damage or inflammation of the white matter of the brain.
External links
- Medical encyclopedia article on Rosenthal fiber
- Wikipedia's article - Rosenthal fiber
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