RIG-I-like receptor

RIG-I-like receptor

The RIG-I-like receptor (pronounced as R-I-G-I-like receptor), also known as RLR, is a type of pattern recognition receptor (PRR) that plays a crucial role in the innate immune system. The term "RIG-I-like receptor" is derived from the name of one of its key members, Retinoic acid-inducible gene I (RIG-I).

Etymology

The term "RIG-I-like receptor" is derived from the name of one of its key members, Retinoic acid-inducible gene I (RIG-I). The "like" in the name indicates that the receptors in this family share similar structural and functional characteristics with RIG-I.

Function

RIG-I-like receptors are cytoplasmic sensors that detect viral RNA and initiate the immune response. They are essential for the recognition of viral pathogens and the activation of downstream signaling pathways that lead to the production of interferons and pro-inflammatory cytokines, which are crucial for antiviral defense.

Members

The RIG-I-like receptor family includes three members:

• RIG-I
• MDA5
• LGP2

Each of these members has distinct roles in the immune response to different viruses.

Related Terms

• Pattern Recognition Receptor (PRR)
• Interferon
• Cytokine
• RIG-I
• MDA5
• LGP2

External links

• Medical encyclopedia article on RIG-I-like receptor
• Wikipedia's article - RIG-I-like receptor

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