Psoriatic juvenile idiopathic arthritis

Other Names: Juvenile psoriatic arthritis; Psoriasis-related JIA; Psoriasis-related juvenile idiopathic arthritis

Psoriatic juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis that is characterized by both arthritis and psoriasis.

Cause and risk factors

Although the underlying cause of psoriatic juvenile idiopathic arthritis is currently unknown (idiopathic), it is thought to occur due to a combination of genetic and environmental factors. It is very rare for more than one member of a family to have juvenile arthritis; however, research suggests that having a family member with juvenile arthritis or any autoimmune disease may increase the risk of having juvenile arthritis, in general.

Signs and symptoms

signs and symptoms may include dactylitis (inflammation and swelling of an entire finger or toe); nail pitting or splitting; and eye problems. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. 80%-99% of people have these symptoms

• Abnormality of tumor necrosis factor secretion

30%-79% of people have these symptoms

• Antinuclear antibody positivity
• Arthralgia(Joint pain)
• Enthesitis
• Finger dactylitis(Sausage fingers)
• Nail pits(Nail pitting)
• Oligoarthritis
• Polyarticular arthritis
• Pruritus(Itching)
• Psoriasiform dermatitis
• Toe dactylitis(Sausage toes)

5%-29% of people have these symptoms

• Abnormality of the knee
• Abnormality of the shoulder
• Abnormality of the wrist(Abnormalities of the wrists)
• Generalized morning stiffness
• Malar rash
• Psoriasiform lesion
• Reduced visual acuity(Decreased clarity of vision)

Treatment

The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition.

• Methotrexate oral solution (Brand name: Xatmep) methotrexate oral solution (Xatmep) was approved for the treatment of oligoarticular juvenile idiopathic arthritis (persistent oligoarthritis, psoriatic juvenile idiopathic arthritis, enthesitis-related arthritis, or undifferentiated arthritis) and polyarticular juvenile idiopathic arthritis in children 0 through 16 years of age.

NIH genetic and rare disease info

• NIH info on Psoriatic juvenile idiopathic arthritis

Psoriatic juvenile idiopathic arthritis is a rare disease.