Prostaglandin EP3 receptor

Prostaglandin EP3 receptor (EP3) is a G protein-coupled receptor that in humans is encoded by the PTGER3 gene. It is one of the four receptors for prostaglandin E2 (PGE2), and through the prostaglandin-endoperoxide synthase pathway, plays a role in a variety of physiological and pathological processes.

Function

The EP3 receptor is one of the four identified G protein-coupled receptors for prostaglandin E2 (PGE2). Prostaglandin E2 has been implicated in numerous physiological and pathological processes, including immune response, inflammation, sleep-wake cycle regulation, and smooth muscle contraction. The EP3 receptor is known to couple to inhibitory G proteins and is involved in the inhibition of adenylate cyclase activity.

Gene

The PTGER3 gene encoding the EP3 receptor is located on human chromosome 1. The gene is complex by virtue of multiple promoters and alternative splicing, resulting in at least eight different isoforms of the receptor, each with distinct signaling properties.

Clinical significance

EP3 receptor has been implicated in a variety of diseases and disorders, including rheumatoid arthritis, atherosclerosis, Alzheimer's disease, and cancer. It is also involved in the regulation of fever and pain perception. Inhibition of the EP3 receptor has been proposed as a potential therapeutic strategy for these conditions.

See also

• Prostaglandin receptors
• Prostaglandin E2
• G protein-coupled receptor
• PTGER3

References

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