Prosorba column

Prosorba Column

The Prosorba Column (pronunciation: pro-SOR-ba column) is a medical device used for the treatment of rheumatoid arthritis. It is a type of immunoadsorption therapy that selectively removes autoantibodies and immune complexes from the blood.

Etymology

The term "Prosorba" is a combination of the words "protein" and "absorb", reflecting the device's function of absorbing proteins (specifically, autoantibodies and immune complexes) from the blood. The word "column" refers to the physical shape of the device.

Function

The Prosorba Column is a cylindrical device filled with a polymer known as protein A. This protein has a high affinity for the Fc region of IgG antibodies, allowing it to bind and remove these antibodies from the blood. The blood is then returned to the patient's body, minus the harmful autoantibodies and immune complexes.

Use in Treatment

The Prosorba Column is used in the treatment of severe rheumatoid arthritis, particularly in patients who have not responded to other treatments. The procedure is typically performed once a week for 12 weeks. While it can be effective, it is not without risks, and potential side effects include anemia, infection, and thrombosis.

Related Terms

• Rheumatoid arthritis
• Immunoadsorption
• Autoantibodies
• Immune complexes
• Protein A
• Fc region
• IgG
• Anemia
• Infection
• Thrombosis

External links

• Medical encyclopedia article on Prosorba column
• Wikipedia's article - Prosorba column

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