PHF10

PHF10 is a human gene that encodes for the protein PHD finger protein 10. This protein is a part of the histone-modifying PHD finger protein family, which plays a crucial role in chromatin remodeling.

Function

PHF10 is involved in the regulation of cell cycle and cell differentiation. It is a subunit of the PAF1 complex, which is associated with RNA polymerase II and functions in transcriptional regulation and elongation. The PHF10 protein has been found to interact with cyclin-dependent kinase 2 (CDK2), suggesting its role in cell cycle progression.

Clinical Significance

Alterations in the PHF10 gene have been associated with several types of cancer, including breast cancer and lung cancer. Overexpression of PHF10 has been observed in these cancers, suggesting its potential role as an oncogene.

Structure

The PHF10 protein contains a PHD finger domain, which is a common motif in proteins involved in chromatin remodeling. This domain allows the protein to bind to histone proteins and modify their structure, thereby influencing gene expression.

Research

Research is ongoing to understand the precise role of PHF10 in cancer development and progression. It is hoped that this research could lead to the development of new therapeutic strategies for cancer treatment.

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External links

• PHF10 at the National Center for Biotechnology Information
• PHF10 at GeneCards

See also

• PHD finger protein
• PAF1 complex
• Histone
• Chromatin
• Cell cycle
• Cell differentiation
• Transcription (genetics)
• Cancer
• Oncogene
• Breast cancer
• Lung cancer