PD-L1
| PD-L1 | |
|---|---|
| Term | PD-L1 |
| Short definition | PD-L1 - A protein that acts as a kind of "brake" to keep the body's immune responses under control. PD-L1 can be found on some normal cells and at higher than normal levels on some types of cancer cells. |
| Type | Cancer terms |
| Specialty | Oncology |
| Language | English |
| Source | NCI |
| Comments | |
PD-L1 - A protein that acts as a kind of "brake" to keep the body's immune responses under control. PD-L1 can be found on some normal cells and at higher than normal levels on some types of cancer cells. When PD-L1 binds to another protein called PD-1 (a protein found on T cells), it stops the T cells from killing PD-L1-containing cells, including cancer cells. Cancer drugs called immune checkpoint inhibitors bind to PD-L1 and block its binding to PD-1. This releases the “brakes” on the immune system, freeing up T cells to kill cancer cells
External links
- Medical encyclopedia article on PD-L1
- Wikipedia's article - PD-L1
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