Noroxycodone
Noroxycodone
Noroxycodone (pronunciation: nor-ox-i-KOE-done) is a major metabolite of the opioid analgesic oxycodone. It is primarily excreted in the urine and is considered to have negligible analgesic effects.
Etymology
The term "Noroxycodone" is derived from the parent drug "oxycodone". The prefix "nor-" is derived from the word "normal", which in chemical nomenclature indicates the removal of a methyl group from the parent molecule.
Pharmacology
Noroxycodone is produced in the liver by the enzyme CYP3A4, which metabolizes oxycodone into noroxycodone, a process known as N-demethylation. Despite being a major metabolite, noroxycodone has significantly less analgesic effect than its parent compound, oxycodone. This is due to its poor ability to cross the blood-brain barrier.
Related Terms
- Oxycodone: The parent drug from which noroxycodone is metabolized.
- CYP3A4: The enzyme responsible for the metabolism of oxycodone into noroxycodone.
- N-demethylation: The metabolic process by which noroxycodone is produced from oxycodone.
- Blood-brain barrier: A semipermeable barrier that prevents certain substances, including noroxycodone, from entering the brain.
See Also
External links
- Medical encyclopedia article on Noroxycodone
- Wikipedia's article - Noroxycodone
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