Norhydrocodone
Norhydrocodone
Norhydrocodone (pronunciation: nor-hy-dro-co-done) is a major active metabolite of the opioid Hydrocodone. It is formed in the liver via the cytochrome P450 enzyme CYP3A4.
Etymology
The term "Norhydrocodone" is derived from the words "nor", a prefix in organic chemistry signifying the absence of a functional group, in this case, a methyl group, and "hydrocodone", the parent compound from which it is metabolized.
Pharmacology
Norhydrocodone exhibits its own analgesic effects, contributing to the overall analgesic effect of hydrocodone. It is less potent than its parent compound, hydrocodone, but is present in higher concentrations in the plasma due to its longer half-life.
Metabolism
Norhydrocodone is primarily metabolized by the liver enzyme CYP3A4, but also by CYP2D6. It is one of the three main metabolites of hydrocodone, the others being Hydromorphone and Dihydrocodeine.
Related Terms
- Hydrocodone: The parent compound from which norhydrocodone is metabolized.
- CYP3A4: The primary liver enzyme responsible for the metabolism of norhydrocodone.
- CYP2D6: Another liver enzyme involved in the metabolism of norhydrocodone.
- Hydromorphone: Another major metabolite of hydrocodone.
- Dihydrocodeine: Another major metabolite of hydrocodone.
External links
- Medical encyclopedia article on Norhydrocodone
- Wikipedia's article - Norhydrocodone
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