Norgestimate

Norgestimate (pronounced: nor-JES-ti-mate) is a progestin medication which is used in birth control pills and in menopausal hormone therapy. It is available only as a combination formulation with the estrogen ethinylestradiol.

Etymology

The term "Norgestimate" is derived from its chemical name, 17α-ethinyl-18-methyl-19-nor-δ4,20-testosterone-3-oxime acetate.

Pharmacology

Norgestimate is a prodrug that is metabolized in the body to the active metabolite, norelgestromin. It works mainly by preventing the release of an egg during the menstrual cycle. It also makes vaginal fluid thicker to help prevent sperm from reaching an egg (fertilization) and changes the lining of the uterus (womb) to prevent attachment of a fertilized egg.

Usage

Norgestimate is used in combination with an estrogen in contraceptive pills to prevent pregnancy. It is also used in menopausal hormone therapy to treat symptoms of menopause.