N-Methylnorcarfentanil

N-Methylnorcarfentanil is a potent opioid analgesic drug that is an analog of fentanyl. It is one of the most potent opioids known, being over 100 times stronger than fentanyl.

Chemistry

N-Methylnorcarfentanil is a 4-anilidopiperidine derivative, which is a class of synthetic opioids that also includes the fentanyl analogs. It has a methyl group attached to the nitrogen atom in the piperidine ring, which is a structural modification that significantly increases the potency of the drug.

Pharmacology

Like other opioids, N-Methylnorcarfentanil works by binding to the mu-opioid receptor in the brain, spinal cord, and other parts of the body. This binding action inhibits the transmission of pain signals and produces a feeling of euphoria. The drug's high potency is due to its high lipophilicity, which allows it to rapidly cross the blood-brain barrier and exert its effects.

Effects

The effects of N-Methylnorcarfentanil are similar to those of other opioids and include analgesia, sedation, euphoria, and respiratory depression. Due to its high potency, the risk of overdose and death is significantly higher than with other opioids.

Legal Status

N-Methylnorcarfentanil is a controlled substance in many countries due to its high potential for abuse and addiction. In the United States, it is classified as a Schedule I drug under the Controlled Substances Act.

See Also

• Fentanyl
• Opioid
• Mu-opioid receptor

References

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  N-Methylcarfentanil structure

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  N-Methylnorcarfentanil