Monoamine oxidase b

Monoamine oxidase B (pronounced: mon-o-amine ox-i-dase B), often abbreviated as MAO-B, is an enzyme in the human body that plays a crucial role in the metabolism of neurotransmitters.

Etymology

The term "Monoamine oxidase B" is derived from its function. "Monoamine" refers to the type of amines it acts upon, "oxidase" refers to its ability to oxidize these amines, and "B" differentiates it from its counterpart, Monoamine oxidase A (MAO-A).

Function

MAO-B is found in the mitochondria of most cell types in the body. It is involved in the breakdown of several neurotransmitters, including dopamine, phenethylamine, and benzylamine. By breaking down these neurotransmitters, MAO-B helps regulate their levels in the brain, which is important for maintaining normal brain function.

Clinical significance

Inhibitors of MAO-B, such as selegiline and rasagiline, are used in the treatment of Parkinson's disease. These drugs work by preventing the breakdown of dopamine, thereby increasing its availability in the brain. This can help alleviate some of the symptoms of Parkinson's disease.

Related terms

• Monoamine oxidase A: The other form of monoamine oxidase found in the body.
• Neurotransmitter: Chemicals that transmit signals across a synapse.
• Dopamine: A neurotransmitter that plays several important roles in the brain and body.
• Parkinson's disease: A long-term degenerative disorder of the nervous system that mainly affects the motor system.

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