Mizoribine

Mizoribine

Mizoribine (pronounced: mi-zo-ri-bine) is an immunosuppressive agent used primarily in the field of transplantation medicine to prevent organ rejection. It is also used in the treatment of certain autoimmune diseases.

Etymology

The name "Mizoribine" is derived from the fungus Eupenicillium brefeldianum, from which it was first isolated in 1974 by Japanese scientists. The fungus was discovered in a soil sample from the Mizoro district of Japan, hence the name "Mizoribine".

Pharmacology

Mizoribine is an inosine monophosphate dehydrogenase inhibitor, which means it inhibits the synthesis of DNA and RNA, thereby suppressing the immune system. It is particularly effective in preventing the proliferation of lymphocytes, a type of white blood cell that plays a key role in the immune response.

Clinical Use

In transplantation medicine, Mizoribine is used to prevent the body's immune system from rejecting a transplanted organ. It is also used in the treatment of certain autoimmune diseases, such as rheumatoid arthritis and lupus erythematosus, where the body's immune system mistakenly attacks its own tissues.

Side Effects

Like all immunosuppressive agents, Mizoribine can have serious side effects. These may include infections, anemia, leukopenia (a decrease in white blood cells), and thrombocytopenia (a decrease in platelets). Patients taking Mizoribine should be closely monitored for these and other potential side effects.

Related Terms

• Immunosuppressive agent
• Transplantation medicine
• Organ rejection
• Autoimmune diseases
• Inosine monophosphate dehydrogenase inhibitor
• Lymphocytes
• Rheumatoid arthritis
• Lupus erythematosus

External links

• Medical encyclopedia article on Mizoribine
• Wikipedia's article - Mizoribine

This WikiMD article is a stub. You can help make it a full article.

---

Languages: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski