Methylthiouracil
Methylthiouracil is a thiourea derivative used in the treatment of hyperthyroidism. It belongs to the class of antithyroid agents and works by inhibiting the synthesis of thyroid hormones.
Pharmacology[edit]
Methylthiouracil is a thioamide, a class of drugs that inhibit the production of thyroid hormones by the thyroid gland. It does this by interfering with the incorporation of iodine into thyroglobulin, which is necessary for the synthesis of thyroxine (T4) and triiodothyronine (T3).
Medical uses[edit]
Methylthiouracil is used in the treatment of hyperthyroidism, a condition characterized by an overactive thyroid gland and excessive production of thyroid hormones. It is also used in the preparation for thyroid surgery and for the management of thyroid storm, a severe form of thyrotoxicosis.
Side effects[edit]
The most common side effects of methylthiouracil include skin rash, nausea, vomiting, loss of taste, and abdominal pain. In rare cases, it can cause serious side effects such as hepatitis, neutropenia, and agranulocytosis.
Contraindications[edit]
Methylthiouracil is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with liver disease due to the risk of hepatotoxicity.
See also[edit]
 | This medical article is a stub. You can help WikiMD by expanding the page. |
-
Methylthiouracil structure -
Methylthiouracil 3D model -
Methylthiouracil synthesis
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
