Methyl methanesulfonate

Methyl methanesulfonate

Methyl methanesulfonate (MMS) is a potent alkylating agent and a carcinogen. It is commonly used in laboratories for the induction of DNA damage and mutation studies. MMS is a clear, colorless liquid with a strong, unpleasant odor. It is highly soluble in water and miscible with most organic solvents.

Chemical Properties

Methyl methanesulfonate is an organic compound with the chemical formula CH3SO2OCH3. It belongs to the class of methanesulfonates, which are organic compounds containing a sulfonate group that is S-linked to a methyl group. MMS is a strong methylating agent, capable of transferring a methyl group to DNA, proteins, and other biomolecules.

Biological Effects

MMS is a potent mutagen and carcinogen. It exerts its mutagenic effects by alkylating DNA, leading to the formation of DNA adducts. These adducts can cause errors during DNA replication, leading to mutations. MMS-induced mutations can lead to cancer development. In addition to its mutagenic effects, MMS can also cause cell death by inducing DNA damage that is too severe to be repaired.

Safety

Due to its mutagenic and carcinogenic properties, MMS should be handled with extreme caution. It is classified as a hazardous substance and is subject to strict regulations regarding its use and disposal. Protective clothing, gloves, and eye/face protection should be worn when handling MMS. In case of exposure, immediate medical attention should be sought.

Uses

In the laboratory, MMS is commonly used in mutation studies. It is also used in the synthesis of other chemicals.

See Also

• Alkylating agent
• Carcinogen
• DNA damage
• Mutation

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