Methyl-DMA
Methyl-DMA (also known as MDMA or 3,4-Methylenedioxy-N-methylamphetamine) is a psychoactive drug primarily used for recreational purposes. It is known for its empathogenic effects, where users report feelings of increased empathy, euphoria, and heightened sensations.
History
Methyl-DMA was first synthesized in the early 20th century by the pharmaceutical company Merck. It was initially developed as a potential pharmaceutical treatment for conditions such as hemorrhage and hypotension, but its psychoactive properties were not discovered until the 1970s.
Pharmacology
Methyl-DMA acts primarily as a serotonin-norepinephrine-dopamine releasing agent (SNDRA). It increases the levels of these neurotransmitters in the brain, leading to its psychoactive effects. It also has a high affinity for the serotonin transporter (SERT), which is thought to be a major contributor to its empathogenic effects.
Effects
The effects of Methyl-DMA can vary widely depending on the dose, the user's individual physiology, and the environment in which it is taken. Common effects include feelings of euphoria, increased empathy, heightened sensations, and increased energy. However, it can also cause negative effects such as anxiety, paranoia, and dehydration. In rare cases, it can lead to severe health complications such as hyperthermia, hyponatremia, and serotonin syndrome.
Legal Status
The legal status of Methyl-DMA varies widely around the world. In many countries, including the United States, it is classified as a Schedule I drug, indicating that it has a high potential for abuse and no accepted medical use. However, some countries have more lenient laws regarding its use and possession.
See Also
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Contributors: Prab R. Tumpati, MD