Mengovirus

Mengovirus is a type of virus that belongs to the Picornaviridae family. It is a single-stranded RNA virus that is non-enveloped and has an icosahedral capsid. The virus is known to cause diseases in mice and is often used in scientific research.

Structure and Genome

Mengovirus has a non-enveloped capsid that is icosahedral in shape. The capsid is made up of 60 copies of each of the four viral proteins, VP1, VP2, VP3, and VP4. The virus has a single-stranded RNA genome that is positive-sense. The genome is approximately 7.5 kilobases in length and encodes a single polyprotein.

Replication

The replication of Mengovirus begins with the attachment of the virus to the host cell. The virus enters the cell through receptor-mediated endocytosis. Once inside the cell, the virus uncoats and releases its RNA genome into the cytoplasm. The RNA genome is then translated into a polyprotein by the host's ribosomes. The polyprotein is cleaved into individual proteins by viral proteases. The RNA genome is replicated by the viral RNA-dependent RNA polymerase. The newly synthesized RNA genomes are packaged into capsids to form new virus particles. The new virus particles are released from the cell by lysis.

Pathogenesis and Immunity

Mengovirus is known to cause diseases in mice. The virus can cause encephalomyelitis, which is inflammation of the brain and spinal cord. The virus can also cause myocarditis, which is inflammation of the heart muscle. The immune response to Mengovirus is primarily mediated by the immune system's T cells. The virus is also known to induce a strong antibody response.

Research Use

Mengovirus is often used in scientific research. The virus is used as a model to study viral replication, pathogenesis, and immunity. The virus is also used to study the function of the immune system.

See Also

• Picornaviridae
• RNA virus
• Capsid
• Viral replication
• Viral pathogenesis
• Immune response

References

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