Masitinib mesylate

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Masitinib Mesylate

Masitinib mesylate (pronunciation: ma-si-ti-nib me-si-late) is a type of tyrosine kinase inhibitor used in the treatment of certain types of cancer and inflammatory diseases.

Etymology

The term "Masitinib" is derived from the chemical name 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide mesylate. The "mesylate" suffix indicates that the drug is a salt of methanesulfonic acid.

Usage

Masitinib mesylate is primarily used in the treatment of mastocytosis, a group of disorders caused by an excessive number of mast cells in the body. It is also used in the treatment of certain types of gastrointestinal stromal tumors (GISTs), pancreatic cancer, and rheumatoid arthritis.

Mechanism of Action

Masitinib mesylate works by blocking the action of certain proteins in the body that can affect the growth and spread of cancer cells. It specifically targets and inhibits the tyrosine kinases c-Kit, PDGFR, and FGFR3, which are involved in cell proliferation and survival.

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