Masitinib mesylate
Masitinib Mesylate
Masitinib mesylate (pronunciation: ma-si-ti-nib me-si-late) is a type of tyrosine kinase inhibitor used in the treatment of certain types of cancer and inflammatory diseases.
Etymology
The term "Masitinib" is derived from the chemical name 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide mesylate. The "mesylate" suffix indicates that the drug is a salt of methanesulfonic acid.
Usage
Masitinib mesylate is primarily used in the treatment of mastocytosis, a group of disorders caused by an excessive number of mast cells in the body. It is also used in the treatment of certain types of gastrointestinal stromal tumors (GISTs), pancreatic cancer, and rheumatoid arthritis.
Mechanism of Action
Masitinib mesylate works by blocking the action of certain proteins in the body that can affect the growth and spread of cancer cells. It specifically targets and inhibits the tyrosine kinases c-Kit, PDGFR, and FGFR3, which are involved in cell proliferation and survival.
Related Terms
- Tyrosine kinase inhibitor
- Mastocytosis
- Gastrointestinal stromal tumor
- Pancreatic cancer
- Rheumatoid arthritis
External links
- Medical encyclopedia article on Masitinib mesylate
- Wikipedia's article - Masitinib mesylate
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