Mariana J. Kaplan

American rheumatologist and researcher

Mariana J. Kaplan

Mariana J. Kaplan is a prominent American rheumatologist and researcher known for her work in the field of autoimmune diseases, particularly systemic lupus erythematosus (SLE). She is recognized for her contributions to understanding the role of the immune system in the pathogenesis of autoimmune disorders.

Early life and education

Mariana J. Kaplan was born in Mexico City, Mexico. She pursued her medical degree at the National Autonomous University of Mexico (UNAM), where she developed an interest in rheumatology. Following her graduation, she completed her residency in internal medicine and a fellowship in rheumatology at the National Institute of Medical Sciences and Nutrition Salvador Zubirán.

Career

Kaplan began her career as a clinician and researcher, focusing on the mechanisms of autoimmunity and inflammation. She moved to the United States to further her research and joined the faculty at the University of Michigan, where she became a leading figure in rheumatology research.

Research contributions

Kaplan's research has significantly advanced the understanding of neutrophil function in autoimmune diseases. Her work has elucidated the role of neutrophil extracellular traps (NETs) in the pathogenesis of SLE and other autoimmune conditions. She has also investigated the impact of type I interferons and vascular damage in lupus patients.

Current position

Mariana J. Kaplan is currently a senior investigator at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health (NIH). Her laboratory continues to explore the cellular and molecular mechanisms that contribute to the development and progression of autoimmune diseases.

Awards and honors

Kaplan has received numerous awards for her contributions to medical research, including the Henry Kunkel Young Investigator Award from the American College of Rheumatology. She is also a member of several professional organizations and has served on the editorial boards of leading rheumatology journals.

Personal life

Mariana J. Kaplan is married and has two children. She is an advocate for women in science and actively mentors young researchers in the field of rheumatology.

Related pages

• Systemic lupus erythematosus
• Autoimmune disease
• Rheumatology
• National Institutes of Health