MLLT1

MLLT1 (also known as ENL or LTG19) is a gene that encodes a protein involved in transcriptional elongation. The protein is a component of the super elongation complex (SEC), a major regulator of transcriptional elongation transcriptional elongation.

Function

The MLLT1 gene is known to encode a protein that is a component of the super elongation complex (SEC). The SEC plays a crucial role in controlling the rate of transcription elongation by RNA polymerase II, which is a key step in gene expression. The MLLT1 protein is thought to have a role in leukemogenesis.

Clinical significance

Alterations and mutations in the MLLT1 gene have been implicated in certain types of leukemia, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). In particular, translocations involving the MLLT1 gene are associated with poor prognosis in these diseases.

Research

Research into the MLLT1 gene and its associated protein is ongoing, with a focus on understanding its role in normal cellular function and in disease states, particularly leukemia. This research may lead to new therapeutic strategies for treating leukemia and other diseases in which the MLLT1 gene is implicated.

See also

• Super elongation complex
• Transcription (biology)
• Acute lymphoblastic leukemia
• Acute myeloid leukemia

References

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