Lipoarabinomannan

Lipoarabinomannan (pronunciation: /ˌlaɪpoʊˌærəˈbɪnoʊˌmænən/), often abbreviated as LAM, is a lipoglycan found in the cell wall of Mycobacterium species, including the pathogenic species Mycobacterium tuberculosis.

Etymology

The term "Lipoarabinomannan" is derived from its structure. "Lipo-" refers to the lipid component, "-arabino-" refers to the arabinose sugars, and "-mannan" refers to the mannose sugars.

Structure

Lipoarabinomannan is composed of a mannose-polysaccharide core, an arabinose-containing branching polysaccharide, and a lipid component consisting of a series of long-chain fatty acids.

Function

Lipoarabinomannan plays a crucial role in the pathogenicity and virulence of Mycobacterium tuberculosis. It interferes with the host's immune response, inhibits the fusion of phagosome with lysosome, and induces the release of cytokines.

Related Terms

External links

Medical encyclopedia article on Lipoarabinomannan
Wikipedia's article - Lipoarabinomannan

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Lipoarabinomannan