Ligelizumab
Ligelizumab is a monoclonal antibody designed for the treatment of chronic spontaneous urticaria (CSU). It is developed by Novartis, a Swiss multinational pharmaceutical company. Ligelizumab works by targeting and neutralizing immunoglobulin E (IgE), a type of antibody that plays a key role in allergic reactions.
Mechanism of Action
Ligelizumab is a monoclonal antibody that binds to IgE, preventing it from attaching to mast cells and basophils. This inhibits the release of inflammatory mediators like histamine, which are responsible for the symptoms of CSU.
Clinical Trials
Ligelizumab has undergone several clinical trials to evaluate its safety and efficacy. In a Phase IIb study, ligelizumab demonstrated superior efficacy compared to omalizumab, another IgE inhibitor, in patients with CSU who were unresponsive to antihistamines.
Approval
As of 2021, ligelizumab is not yet approved by the Food and Drug Administration (FDA) or the European Medicines Agency (EMA). However, it is under review by these regulatory bodies.
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Contributors: Prab R. Tumpati, MD
