Langerhans cell sarcoma
Langerhans Cell Sarcoma
Langerhans Cell Sarcoma (pronunciation: LAN-ger-hanz sel sar-KO-ma) is a rare and aggressive neoplasm that originates from Langerhans cells, which are specialized dendritic cells found in the skin and mucosa.
Etymology
The term "Langerhans" is named after the German physician Paul Langerhans, who first described these cells in 1868. "Cell" refers to the basic unit of life, and "Sarcoma" is derived from the Greek word sarkoma, which means fleshy growth.
Definition
Langerhans Cell Sarcoma is a type of cancer that primarily affects the skin, but can also involve other organs such as the lymph nodes, liver, spleen, and bone marrow. It is characterized by the proliferation of malignant Langerhans cells that do not express Epidermal Growth Factor Receptor (EGFR).
Symptoms
Symptoms of Langerhans Cell Sarcoma can vary depending on the organs involved, but may include skin lesions, lymphadenopathy, hepatosplenomegaly, and anemia.
Diagnosis
Diagnosis of Langerhans Cell Sarcoma is often challenging due to its rarity and nonspecific symptoms. It typically involves a combination of histopathology, immunohistochemistry, and molecular genetic studies.
Treatment
Treatment options for Langerhans Cell Sarcoma include surgery, radiation therapy, and chemotherapy. The choice of treatment depends on the stage of the disease, the patient's overall health, and the organs involved.
Prognosis
The prognosis of Langerhans Cell Sarcoma is generally poor due to its aggressive nature and resistance to treatment. However, early detection and treatment can improve survival rates.
See Also
External links
- Medical encyclopedia article on Langerhans cell sarcoma
- Wikipedia's article - Langerhans cell sarcoma
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