LPAR5

LPAR5

Symbol	LPAR5
HGNC ID	20466
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	12p13.33
Locus supplementary data	–

LPAR5 (Lysophosphatidic acid receptor 5) is a G protein-coupled receptor (GPCR) that is encoded by the LPAR5 gene in humans. This receptor is part of the lysophosphatidic acid receptor family, which is involved in various cellular processes, including cell proliferation, migration, and survival.

Function

LPAR5 is activated by lysophosphatidic acid (LPA), a bioactive lipid that acts as a signaling molecule. Upon activation, LPAR5 can initiate multiple downstream signaling pathways, influencing cellular responses such as cytoskeletal reorganization, cell motility, and immune response.

Expression

The expression of LPAR5 is found in various tissues, including the central nervous system, immune cells, and gastrointestinal tract. Its expression pattern suggests a role in neurotransmission, immune regulation, and gastrointestinal function.

Clinical Significance

Alterations in LPAR5 expression or function have been implicated in several diseases, including cancer, fibrosis, and inflammatory disorders. Research is ongoing to understand the potential of LPAR5 as a therapeutic target in these conditions.

See Also

• G protein-coupled receptor
• Lysophosphatidic acid
• Cell signaling

External Links

• LPAR5 on WikiMD
• LPAR5 Gene - NCBI