L-733,060
Chemical compound
| L-733,060 | |
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| CAS Number | 161715-24-8 |
| PubChem | 3083531 |
| DrugBank | |
| ChemSpider | 2341451 |
| KEGG | |
L-733,060 is a chemical compound that acts as a potent and selective antagonist for the neurokinin 1 receptor (NK1 receptor). It is primarily used in scientific research to study the role of substance P and the NK1 receptor in various physiological and pathological processes.
Pharmacology
L-733,060 binds to the NK1 receptor, inhibiting the action of substance P, a neuropeptide involved in processes such as pain, inflammation, and emesis. By blocking this receptor, L-733,060 can help elucidate the role of substance P in these processes and has potential therapeutic implications for conditions like chronic pain, depression, and chemotherapy-induced nausea and vomiting.
Research Applications
L-733,060 is widely used in preclinical studies to investigate the function of the NK1 receptor. It has been instrumental in advancing our understanding of the pathophysiology of various conditions, including anxiety disorders, depression, and inflammatory diseases. Researchers utilize this compound to explore new therapeutic targets and develop novel treatments.
Chemical Properties
L-733,060 has a complex chemical structure characterized by multiple functional groups, including dichlorophenyl, difluorophenyl, and morpholinyl moieties. Its molecular formula is C24H25Cl2F2N3O3, and it has a molecular weight of 528.38 g/mol.
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