ING2

Inhibitor of growth protein 2 (ING2) is a protein that in humans is encoded by the ING2 gene.

Function

ING2 is a member of the inhibitor of growth family of proteins, which are involved in chromatin remodeling and gene expression. ING2 plays a role in the regulation of cell cycle, apoptosis, and DNA repair. It is known to interact with the p53 tumor suppressor protein and is involved in the p53 signaling pathway.

Clinical significance

Alterations in the expression of ING2 have been associated with various types of cancer, including breast cancer, colorectal cancer, and melanoma. ING2 is considered a potential tumor suppressor gene, and its loss of function may contribute to tumorigenesis.

Interactions

ING2 has been shown to interact with several proteins, including:

• TP53 (p53)
• Histone acetyltransferases
• Histone deacetylases

These interactions suggest that ING2 is involved in the regulation of chromatin structure and gene transcription.

See also

• Inhibitor of growth family
• Tumor suppressor gene
• Chromatin remodeling

External links

• ING2 gene - NCBI Gene
• ING2 protein - UniProt