HOXC12

HOXC12

Symbol	HOXC12
HGNC ID	5107
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	12q13.13
Locus supplementary data	–

HOXC12 is a gene that encodes a member of the homeobox family of transcription factors. These proteins play a crucial role in the regulation of developmental processes and cell differentiation. The HOXC12 gene is part of the HOXC gene cluster, which is located on chromosome 12 in humans.

Function

The HOXC12 protein is involved in the regulation of gene expression during embryonic development. It is particularly important in the development of the nervous system and limb formation. Like other homeobox genes, HOXC12 contains a homeodomain, which is a DNA-binding domain that allows the protein to bind to specific DNA sequences and regulate the transcription of target genes.

Clinical Significance

Mutations or dysregulation of HOXC12 and other homeobox genes can lead to developmental disorders and have been implicated in certain types of cancer. Research is ongoing to better understand the specific roles of HOXC12 in these processes and its potential as a target for therapeutic intervention.

See Also

• Homeobox
• Transcription factor
• Gene expression
• Embryonic development

External Links

• HOXC12 Gene - NCBI
• HOXC12 Gene - GeneCards