HHV-8-associated MCD

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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HHV-8-associated Multicentric Castleman Disease
Synonyms	Kaposi sarcoma-associated herpesvirus-associated Multicentric Castleman Disease
Pronounce	N/A
Specialty	N/A
Symptoms	Lymphadenopathy, fever, night sweats, weight loss, fatigue
Complications	Kaposi's sarcoma, lymphoma, organ failure
Onset	Typically in adulthood
Duration	Chronic
Types	N/A
Causes	Infection with Human herpesvirus 8 (HHV-8)
Risks	Immunosuppression, HIV/AIDS
Diagnosis	Biopsy, immunohistochemistry, PCR for HHV-8
Differential diagnosis	Lymphoma, HIV-associated multicentric Castleman disease, autoimmune disorders
Prevention	N/A
Treatment	Antiviral therapy, chemotherapy, immunotherapy
Medication	N/A
Prognosis	Variable, depends on response to treatment
Frequency	Rare
Deaths	Can be fatal if untreated

HHV-8-associated MCD

HHV-8-associated MCD is a rare, non-cancerous lymphoproliferative disorder that is associated with the Human Herpesvirus 8 (HHV-8). This condition is characterized by the overgrowth of lymphocytes, a type of white blood cell, in the lymph nodes.

Symptoms

The symptoms of HHV-8-associated MCD can vary widely, but often include fever, night sweats, weight loss, and fatigue. Some patients may also experience abdominal pain, nausea, and vomiting due to enlargement of the spleen or liver.

Causes

HHV-8-associated MCD is caused by an infection with the Human Herpesvirus 8. This virus is also known to cause Kaposi's sarcoma, a type of cancer that can affect the skin, mouth, and internal organs.

Diagnosis

The diagnosis of HHV-8-associated MCD is typically made through a combination of physical examination, blood tests, and imaging studies. In some cases, a biopsy of the affected lymph node may be necessary to confirm the diagnosis.

Treatment

The treatment of HHV-8-associated MCD typically involves the use of antiviral medications to control the HHV-8 infection, as well as immunomodulatory drugs to reduce the overgrowth of lymphocytes. In severe cases, chemotherapy may be necessary.

Prognosis

The prognosis for patients with HHV-8-associated MCD can vary widely, depending on the severity of the disease and the patient's overall health. However, with appropriate treatment, many patients can achieve a good quality of life.

See also

• Human herpesvirus 8
• Lymphoproliferative disorders
• Kaposi's sarcoma

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