GATA5

GATA5

Symbol	–
HGNC ID	4170
Alternative symbols	–
Entrez Gene	140628
OMIM	611496
RefSeq	NM_080473
UniProt	Q9BWX5
Chromosome	–
Locus supplementary data	–

GATA5 is a gene that encodes a member of the GATA transcription factor family. These transcription factors are characterized by their ability to bind to the GATA DNA sequence and regulate the expression of genes involved in cell differentiation and development.

Function

GATA5 plays a crucial role in the development of various tissues and organs, particularly in the cardiovascular system. It is involved in the regulation of cardiac muscle development and function. GATA5 is also implicated in the development of the endoderm, which gives rise to the gastrointestinal tract and associated organs.

Clinical Significance

Mutations in the GATA5 gene have been associated with several congenital heart defects, including atrial septal defects and ventricular septal defects. Research suggests that GATA5 may also play a role in the development of certain cancers, such as colorectal cancer.

Interactions

GATA5 interacts with other members of the GATA family, such as GATA4 and GATA6, to regulate gene expression. These interactions are important for the proper development of the heart and other organs.

See Also

• GATA transcription factors
• Cardiac development
• Congenital heart defects

External Links

• [GATA5 at GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA5)
• [GATA5 at NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/140628)