Factor ix
Factor IX
Factor IX (pronounced as "factor nine") is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes Hemophilia B. It was formerly known as Christmas factor after Stephen Christmas, the first patient described with a deficiency of this factor.
Etymology
The term "Factor IX" is derived from the Roman numeral for the number nine. It was named as such because it was the ninth factor to be discovered in the blood clotting process. The alternative name, "Christmas factor", is named after Stephen Christmas, the first patient in whom a deficiency of this factor was discovered.
Function
Factor IX is produced by the liver and is involved in the early stages of blood clotting. It is activated by Factor XIa in the intrinsic pathway and by Factor VIIa in the extrinsic pathway. The activated enzyme (Factor IXa) then goes on to activate Factor X.
Related Terms
- Hemophilia B: A blood clotting disorder caused by a mutation of the Factor IX gene, leading to a deficiency of Factor IX.
- Factor XI: This is another clotting factor that is responsible for the activation of Factor IX.
- Factor VII: This clotting factor can also activate Factor IX.
- Factor X: This is the clotting factor that is activated by Factor IXa.
See Also
External links
- Medical encyclopedia article on Factor ix
- Wikipedia's article - Factor ix
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