Fibrinogen

Fibrinogen is a protein produced by the liver. This protein helps stop bleeding by helping blood clots to form. An abnormal level of fibrinogen in the blood can lead to several disorders, including excessive bleeding and thrombosis.

File:Human fibrinogen 3GHG D domain.png

Human fibrinogen 3GHG D domain

Function

Fibrinogen is converted by thrombin into fibrin during the coagulation cascade, which is a series of reactions that occur in the blood. The fibrin strands then stick together and form a clot to prevent excessive bleeding.

Disorders related to Fibrinogen

Abnormal levels of fibrinogen can lead to several disorders. Low levels of fibrinogen can lead to excessive bleeding, while high levels can promote the formation of clots, leading to thrombosis.

Fibrinogen Deficiency

Fibrinogen deficiency is a rare genetic disorder characterized by a deficiency in the production of fibrinogen. This can lead to excessive bleeding or thrombosis.

Fibrinogen Storage Disease

Fibrinogen storage disease is a rare genetic disorder characterized by the accumulation of fibrinogen in the liver, leading to liver disease.

Measurement of Fibrinogen

The level of fibrinogen in the blood can be measured using a blood test. This test can help diagnose disorders related to fibrinogen and can also be used to monitor the effectiveness of treatment.

See Also

• Coagulation
• Thrombosis
• Fibrin
• Blood test