Factor VIII
Factor VIII
Factor VIII (pronounced: Factor Eight) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, Factor VIII is encoded by the F8 gene. Defects in this gene result in Hemophilia A, a recessive X-linked coagulation disorder.
Etymology
The term "Factor VIII" is derived from the classification of blood clotting factors, where it was identified as the eighth factor necessary for proper blood coagulation.
Function
Factor VIII is produced in liver sinusoidal cells and endothelial cells outside of the liver throughout the body. It is involved in the coagulation cascade, specifically acting as a cofactor for Factor IX after it has been activated by Factor XI (or Factor IXa). This results in the formation of a complex on the surface of activated platelets, which ultimately leads to the formation of a blood clot.
Related Terms
- Hemophilia A: A genetic disorder caused by missing or defective Factor VIII, a clotting protein.
- Blood coagulation: The process by which a blood clot forms to stop bleeding.
- Factor IX: Another blood clotting factor that works closely with Factor VIII.
- Factor XI: This factor activates Factor IX, which in turn is activated by Factor VIII.
See Also
External links
- Medical encyclopedia article on Factor VIII
- Wikipedia's article - Factor VIII
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